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KMID : 0974620030210020405
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Bulletin of Dongnam Health University
2003 Volume.21 No. 2 p.405 ~ p.414
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Bioamine Uptake by Amitrityline in Human Plasma
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Jung Ha-Seung
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Abstract
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The bioamine uptake against adrenergic receptor bindings to human platelets was investigated. Amitriptyline displaced the same amount of binding and the binding was sensitive to the medication. Human platelets have been shown to possess high affinity binding sites for adrenergic receptor. These binding sites of this receptor have a similiar affinity and drug specificity to those in rat brains. In synaptic transmission the catecholamine and it’s bindings stimulate the adenylate cyclase activity which reflect the change of biological response. In a rat medicated with amitriptyline to activate metabolites, norepinephrine and epinephrine were increased without change in dopamine, Bmax and Kd in the nerve membrane system. When the depression patients were administrated in amitriptyline to affect as agonist to activate adrenergic receptor the plasma concentrations of circulating norepinephrine and epinephrine were increased without change in dopamine. Such results show that the low plasma levels of norepinephrine could be increased in the disease process of depression patients medicated with amitriptyline as agonist to active metebolites, and so amitriptyline medication could be increased the serum levels of norepinephrine.
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KEYWORD
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